One of the great things to see are those with disabilities overcome them and do things that we take for granted. Playing games is tough but here's a great thread in the PlayStation forums
on one person's customized controller to help him play PlayStation 3 games. He uses his feet, hands, and tongue to operate it all. For those that have a disability and would like to play games, there's help out there for you and these pictures should serve as an inspiration on achieving this feat.